ABSTRACT
Background: Adverse drug reactions (ADRs) are noxious and unintended effects of a drug that occurs at doses normally used in humans. ADRs may also result in diminished quality of life, increased physician visits, hospitalizations, and even death. The objectives of this study are to analyze and assess the causality and severity of reported ADRs.Methods: A cross sectional study of ADRs reported to Pharmacovigilance cell of MNR Medical College and Hospital Sangareddy in a year. The details of the various ADRs were statistically analyzed to find out pattern of ADRs. The WHO-UMC causality category and Hartwig-Seigel Scale were used to assess causality and severity of ADRs respectively.Results: The study shows, out of 60 suspected ADRs, the majority of ADRs were adults (68.3%) and out of whom 56% were females. According to the WHO-UMC Causality categories, 43.3% of the ADRs were categorized under Probable/likely, followed by possible (35%). The Hartwig-Siegel severity assessment scale shows that the majority (90%) of suspected ADRs were of mild category.Conclusions: The pattern of ADRs reported in our study is comparable to other studies. The commonest organ system affected was gastrointestinal tract, nervous and cutaneous system. Antimicrobial agents were causing maximum ADRs and medicine and allied departments have more number of ADRs. This study provides a valuable database for ADRs due to all commonly used drugs at hospitals and also helps in creating awareness regarding safe & judicious use of drugs to prevent ADRs.
ABSTRACT
Background: The Study was designed to assess the awareness of Pharmacovigilance and to evaluate the impact of an educational intervention.Methods: This was a questionnaire-based pre- and post-test educational interventional study. Students were given handouts containing information about pharmacovigilance one month before the educational intervention. A pre-validated 20-point questionnaire on (KAP) Knowledge, attitude, perception about Pharmacovigilance was distributed to second year medical students (n=115). An interactive educational intervention (Power point presentation) was designed. The chi-square test and unpaired paired t-test was used for statistical calculation.Results: The overall response rates were expressed as percentages, Mean±SD. The knowledge, attitude and perceptions of pharmacovigilance when compared before (pre-KAP) and after (post-KAP) the educational intervention, the correct response rates were found to be statistically significant (P<0.001). The feedback from the students was encouraging, handouts before the lecture classes helped them to easily grasp the pharmacovigilance concepts better during lectures.Conclusions: The study concluded that imparting the knowledge about pharmacovigilance and ADR reporting promotes drug safety and rational use of medicines in future.
ABSTRACT
Background: Self-medication practice is widespread in many countries and the irrational use of drugs is a cause of concern. It assumes a special significance among medical students as they are exposed to knowledge about diseases and drugs. To assess practice and perception of self-medication among undergraduate medical students.Methods: It is a descriptive study in which study population was comprised of 2nd year undergraduate medical students of Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka, India. Total 134 students were included in the study. Written informed consent was obtained from each volunteer prior to the study. Students were given a questionnaire that included both open and close ended questions about self-medication practice. Data was analysed and presented as counts and percentages.Results: It was found that 72 (54%) students practiced self-medication. The principal morbidity for seeking self-medication was cold and cough as reported by 70 (53%) students. Antibiotics were most commonly self-medicated as reported by 55 (36%) students. Only 34 (25%) students opined that self-medication is part of self-care.Conclusions: Self-medication is widely practiced among under graduate medical students. In this situation, we should educate the students about advantages and disadvantages of self-medication.